Magnetic Enhanced Delivery Creates Transient Epidermal Pores a Multi-photon Spectrography (mpm–flim) Analysis of Gold Nanoparticle Penetration of Human Epidermis under the Influence of Specifically Configured Magnetic Fields
نویسندگان
چکیده
Pulsed electromagnetic fields (PEMF) and magnetic micro-arrays have been shown to enhance transdermal drug delivery of a wide range of drugs in vitro and in vivo. The mechanisms of actions are believed to relate to diamagnetic repulsion altering diffusion processes and the formation or utilisation of standing or transient pores, shunts and follicles. To investigate the production of transient epidermal pores by pulsed electromagnetic fields (PEMF), the penetration of the epidermis by 10 nm gold nanoparticles was explored using multi-photon microscopy–fluorescent lifetime imaging microscopy (MPM–FLIM) to visualize the stratum corneum penetration of human epidermis with and without magnetic fields.
منابع مشابه
Integrated multimodal optical microscopy for structural and functional imaging of engineered and natural skin.
An integrated multimodal optical microscope is demonstrated for high-resolution, structural and functional imaging of engineered and natural skin. This microscope incorporates multiple imaging modalities including optical coherence (OCM), multi-photon (MPM), and fluorescence lifetime imaging microscopy (FLIM), enabling simultaneous visualization of multiple contrast sources and mechanisms from ...
متن کاملNumerical Simulation of Blood Flow Mixed with Magnetic Nanoparticles under the Influence of AC and DC Magnetic Field
Nanoparticles combined with magnetic fields are one of the most important research areas in the field of biomedical engineering. Direct Current (DC) magnetic and Alternative Current (AC) magnetic fields are often used for controlling nanoparticles. It is also used for hyperthermia treatment. The purpose of the current study is to investigate the effect of DC and AC magnetic field on nanoparticl...
متن کاملEvaluation of Gold Nanoparticle Size Effect on Dose Enhancement Factor in Megavoltage Beam Radiotherapy Using MAGICA Polymer Gel Dosimeter
Background: Gold nanoparticles (GNPs) are among the most promising radiosensitive materials in radiotherapy. Studying the effective sensitizing factors such as nanoparticle size, concentration, surface features, radiation energy and cell type can help to optimize the effect and possible clinical application of GNPs in radiation therapy. In this study, the radiation sensitive polymer gel was use...
متن کاملThree-dimensional calculations of the magnetic fields in a finite superconducting hollow cylinder in an applied axial magnetic field
In this study, a set of self-consistent coupled-integral equations for the local magnetic flux and current distributions in a finite superconducting hollow cylinder under an axial magnetic field has been directly derived by using the Biot-Savart law within the framework of the critical-state model. The equations were first solved numerically in the three-dimensional space before obtaining the h...
متن کاملCoFe2O4 nanoparticles grafted multi-walled carbon nanotubes coupled with surfactant-enhanced spectrofluorimetry for determination of ofloxacin in human plasma
An efficient and simple magnetic solid phase extraction based on the use of CoFe3O4 nanoparticles grafted multi-walled carbon nanotubes (MWCNTs) as adsorbent coupled with surfactant enhanced spectrofluorimetric detection...
متن کامل